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How does this medication work? What will it do for me?

Methotrimeprazine belongs lớn the class of medications called phenothiazines. It is used lớn treat mental và emotional disorders, including schizophrenia, manic-depressive syndromes and other psychotic disorders. It can also be used in conditions associated with anxiety & tension, as a pain reliever (for certain types of pain), as a sedative, và for nausea and vomiting caused by certain conditions.

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This medication may be available under multiple brand names and/or in several different forms. Any specific tên thương hiệu of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people lớn take this medication if their doctor has not prescribed it.


What form(s) does this medication come in?

This medication is available as 5mg & 25mg tablets.

How should I use this medication?

The dose of this medication varies widely depending on the condition being treated and the circumstances & age of the person being treated.

Many things can affect the dose of medication that a person needs, such as body toàn thân weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, vị not change the way that you are taking the medication without consulting your doctor.

It is important khổng lồ take this medication exactly as prescribed by your doctor. If you miss a dose, contact your doctor or pharmacist for advice. Do not take a double dose to make up for a missed one.

Store this medication at room temperature, protect it from light & moisture, và keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. Down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.


Who should NOT take this medication?

Do not take methotrimeprazine if you:

are allergic to lớn methotrimeprazine, or any ingredient of this medication are allergic to other phenothiazines (e.g., chlorpromazine) are excessively sedated by alcohol, sleeping pills, tranquilizers, pain relievers, or narcotics have a blood disorder have liver problems have brain damage have pheochromocytoma (a tumour in the adrenal glands) are being treated with regional or spinal pain relief (epidural infusion) are experiencing severely low blood pressure or severe heart disorder

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response khổng lồ a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks và benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, và some may go away on their own over time.

Contact your doctor if you experience these side effects và they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

decreased sweating drowsiness (appears early in treatment and gradually disappears during the first weeks or with an adjustment in the dosage) dryness of the mouth flu-like symptoms increased skin sensitivity lớn sunlight weight gain

Although most of the side effects listed below don"t happen very often, they could lead khổng lồ serious problems if you vì chưng not kiểm tra with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

difficulty urinating fast or irregular heartbeat, high or low blood pressure high blood sugar (symptoms include increased thirst, decreased appetite, nausea & vomiting) low blood pressure (symptoms include dizziness, especially when moving to lớn a standing position) new or worsening constipation signs of infection (symptoms may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness) signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools) vision changes

Stop taking the medication & seek immediate medical attention if any of the following occur:

allergic reactions, such as skin rash, redness, or itching increased sweating, confusion, or reduced consciousness muscle twitching or uncontrolled movements of the mouth, tongue, face, or jaw painful erection lasting more than 4 hours respiratory infection, fever, flu-like symptoms, coughing, difficult or fast breathing shaking, muscle stiffness, body toàn thân spasm, impairment of voluntary movement, upward eye rolling, exaggeration of reflexes or drooling seizures

Some people may experience side effects other than those listed. check with your doctor if you notice any symptom that worries you while you are taking this medication.


Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure khổng lồ inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, & any other significant facts about your health. These factors may affect how you should use this medication.

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Abnormal heart rhythms: This medication can cause abnormal heart rhythms. Certain medications (e.g., sotalol, quinidine, thioridazine, chlorpromazine, droperidol, pimozide, moxifloxacin, mefloquine, pentamidine, arsenic trioxide, probucol, tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, và should not be used in combination with methotrimeprazine. You are more at risk for this type of abnormal heart rhythm và its complications if you:

are female are older than 65 years of age have a family history of sudden cardiac death have a history of heart disease or abnormal heart rhythms have a slow heart rate have congenital prolongation of the QT interval have diabetes have had a stroke have low potassium, magnesium, or calcium levels have nutritional deficiencies

If you have heart disease và abnormal heart rhythms, or are taking certain medications (e.g., verapamil, atazanavir), discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing & effectiveness of this medication, & whether any special monitoring is needed.

Blood clots: Rarely, this medication may increase the chance of blood clot formation, causing reduction of blood flow to lớn organs or the extremities. If you have a history of clotting you may be at increased risk of experiencing blood clot-related problems such as heart attack, stroke, or clots in the deep veins of your leg. Discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

If you experience symptoms such as sharp pain và swelling in the leg, difficulty breathing, chest pain, blurred vision, or difficulty speaking, contact your doctor immediately.

Body temperature: Methotrimeprazine, like other antipsychotic medications, may interfere with your body"s ability lớn regulate toàn thân temperature. People who exercise vigorously, who are exposed lớn extreme heat, are dehydrated, or are taking anticholinergic medications (e.g., benztropine, oxybutynin) are more at risk. Liên hệ your doctor as soon as possible if you feel very hot and are unable to lớn cool.

Take care to avoid overheating during strenuous exercise or in hot temperatures, and avoid becoming dehydrated by drinking enough fluids.

Diabetes: Methotrimeprazine may increase blood sugar for people with diabetes or those who are at risk for diabetes. If you have diabetes, monitor your blood sugar frequently as recommended by your doctor. If you experience symptoms of high blood sugar (e.g., increased urination, increased thirst, increased eating, and weakness) while taking this medication, contact your doctor.

Dizziness/lightheadedness: In high doses, dizziness or lightheadedness when getting up from a sitting or lying position may be experienced at the start of treatment. To reduce the possibility of experiencing this, rise slowly from a sitting or lying position.

Drowsiness/reduced alertness: Methotrimeprazine can cause drowsiness and reduced alertness, especially during the first few days of treatment. Avoid driving, operating machinery, or performing other tasks that require mental alertness until you have determined how this medication affects you.

Glaucoma: This medication may cause the symptoms of glaucoma (increased pressure in the eye) khổng lồ become worse. If you have glaucoma, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, và whether any special monitoring is needed. Report any changes in vision to your doctor as soon as possible while you are taking this medication.

Neuroleptic malignant syndrome (NMS): This medication may cause a potentially fatal reaction called neuroleptic malignant syndrome (NMS). If you develop symptoms of NMS, such as muscle stiffness, fever, confusion, sweating, or irregular heartbeat, stop taking this medication & seek immediate medical attention.

Tardive dyskinesia: People taking this medication may develop tardive dyskinesia, a syndrome of uncontrolled toàn thân movements. This syndrome may be irreversible. If you develop uncontrolled or unusual toàn thân movements, tương tác your doctor as soon as possible.

Urinary tract problems: This medication can cause the symptoms of some urinary tract problems lớn become worse. If you have an enlarged prostate or another condition that causes urination khổng lồ be difficult, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing & effectiveness of this medication, and whether any special monitoring is needed.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. Infants born to mothers who used methotrimeprazine in the later part of pregnancy have had abnormal muscle movement & withdrawal symptoms, including decreased muscle tone, sleepiness, difficulty feeding và severe difficulty breathing after birth. These symptoms can be severe và need medical attention. If you become pregnant while taking this medication, liên hệ your doctor immediately.

Breast-feeding: Methotrimeprazine passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk lớn your doctor about whether you should continue breast-feeding.

Seniors: Seniors with dementia who take this medication may be at an increased risk of death due either heart disease or infections compared to seniors who are not taking this medication. The use of methotrimeprazine by older adults is not recommended.

What other drugs could interact with this medication?

There may be an interaction between methotrimeprazine and any of the following:

aclidinium alcohol alfuzosin amiodarone antacids (e.g., aluminum hydroxide, magnesium hydroxide) antihistamines (e.g., cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine) anti-malarial medications (e.g., chloroquine, hydroxychloroquine, primaquine) anti-Parkinsons medications (e.g., amantadine, apomorphine, bromocriptine, levodopa, pramipexole, ropinirole) antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone) amphetamines (e.g., dextroamphetamine, lisdexamfetamine) atomoxetine atropine azelastine barbiturates (e.g., butalbital, phenobarbital) belladonna benzodiazepines (e.g., alprazolam, diazepam, lorazepam) benztropine beta-adrenergic blockers (e.g., metoprolol, propranolol, sotalol) botulinum toxin brimonidine bromocriptine bupropion buspirone cannabis chloral hydrate darifenacin degarelix dextromethorphan diabetes medications (e.g., chlorpropamide, glipizide, glyburide, insulin, metformin, rosiglitazone) disopyramide dofetilide domperidone donepezil dronedarone efavirenz ergot alkaloids (e.g., ergotamine, dihydroergotamine) flavoxate flecainide galantamine general anesthetics (medications used lớn put people to lớn sleep before surgery) glucagon glycopyrrolate guanethidine ipratropium lithium lopinavir macrolide antibiotics (e.g., clarithromycin, erythromycin) methadone methylphenidate metoclopramide mexiletine mifepristone mirabegron mirtazapine monoamine oxidase inhibitors (MAOIs; e.g., moclobemide, rasagiline, selegiline, tranylcypromine) muscle relaxants (e.g., baclofen, cyclobenzaprine, methocarbamol, orphenadrine, tizanidine) nabilone narcotic pain relievers (e.g., codeine, fentanyl, morphine, oxycodone) nefazodone nitroglycerin olopatadine oxybutynin porfimer pregabalin procainamide propafenone pseudoephedrine quinidine quinine quinolone antibiotics (e.g., ciprofloxacin, norfloxacin, ofloxacin) rilpivirine rivastigmine St. John"s wort saquinavir seizure medications (e.g., clobazam, levetiracetam, phenobarbital, phenytoin, primidone, topiramate, valproic acid, zonisamide) serotonin antagonists (anti-emetic medications; e.g., granisetron, ondansetron) serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., desvenlafaxine, duloxetine, venlafaxine) selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, paroxetine, sertraline) sodium oxybate sotalol tamoxifen tamsulosin tetrabenazine thalidomide thiazide diuretics (water pills; e.g., hydrochlorothiazide, indapamide, metolazone) tiotropium tolterodine tramadol trazodone tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine) "triptan" migraine medications (e.g., eletriptan, sumatriptan) tryptophan certain tyrosine kinase inhibitors (e.g., lapatinib, pazopanib, sunitinib) umeclidinium voriconazole zopiclone zolpidem

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications, change one of the medications to another, change how you are taking one or both of the medications, or leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak khổng lồ your doctor about how any drug interactions are being managed or should be managed.

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Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), & herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the kích hoạt of many medications, you should let your prescriber know if you use them.