Bi Mat Cua Nhung Bi Mat : Hoc Moi, Van: Amazon

Author liên kết open overlay panelNancy R.Webb‡Patrice M.Connell‡Gregory A.Graf§Eric J.Smart§Willem Villiers‡Frederick Beer‡¶Deneys R.van der Westhuyzen‡

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The scavenger receptor class B, type I (SR-BI), binds high mật độ trùng lặp từ khóa lipoprotein (HDL) và mediates selective sầu uptake of cholesteryl ester from HDL & HDL-dependent cholesterol efflux from cells. We recently identified a new mRNA variant that differs from the previously characterized khung in that the encoded C-terminal cytoplasmic domain name is almost completely different. In the present study, we demonstrate that the mRNAs for mouse SR-BI and SR-BII (previously termed SR-BI.2) are the alternatively spliced products of a single gen. The translation products predicted from human, bovine, mouse, hamster, và rat cDNAs exhibit a high degree of sequence similarity within the SR-BII C-terminal domain name (62–67% identity when compared with the human sequence), suggesting that this variant is biologically important. SR-BII protein represents approximately 12% of the total immunodetectable SR-BI/II protein in mouse liver. Subcellular fractionation of transfected Chinese hamster ovary cells showed that SR-BII, lượt thích SR-BI, is enriched in caveolae, indicating that the altered cytoplasmic tail does not affect targeting of the receptor. SR-BII mediated both selective sầu cellular uptake of cholesteryl ether from HDL as well as HDL-dependent cholesterol efflux from cells, although with approximately 4-fold lower efficiency than SR-BI. In vivo studies using adenoviral vectors showed that SR-BII was relatively less efficient than SR-BI in reducing plasma HDL cholesterol. These studies show that SR-BII, an HDL receptor isosize containing a distinctly different cytoplasmic tail, mediates selective lipid transfer between HDL & cells, but with a lower efficiency than the previously characterized variant.

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*This work was supported by National Institutes of Health Grants AG-14668 (khổng lồ F. C. deB.), HL-58475 (lớn E. J. S.), Grant-in-aid KY-97-GS-2 from American Heart Association, Council for Tobacco Retìm kiếm funds, & Veterans Administration Retìm kiếm Funds.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked “advertisement ” in accordance with 18 U.S.C. Section 1734 solely khổng lồ indicate this fact.

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