Preview Highlights From Asia At Art Basel In Basel 2019

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Lisa S Chow 1 ,Douglas G Mashek 2 ,Erin Austin 3 ,Lynn E Eberly 3 ,Xuan-Mai Persson 4 ,Mara T Mashek 2 ,Elizabeth R Seaquist 5 ,Michael D Jensen 4


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umn.edu. 2 Department of Food Science & Nutrition, University of Minnesota, Minneapolis, Minnesota; 3 Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota; and. 4 Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota. 5 Department of Medicine, University of Minnesota, Minneapolis, Minnesota;


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Lisa S Chow 1 ,Douglas G Mashek 2 ,Erin Austin 3 ,Lynn E Eberly 3 ,Xuan-Mai Persson 4 ,Mara T Mashek 2 ,Elizabeth R Seaquist 5 ,Michael D Jensen 4


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umn.edu. 2 Department of Food Science & Nutrition, University of Minnesota, Minneapolis, Minnesota; 3 Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota; and. 4 Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota. 5 Department of Medicine, University of Minnesota, Minneapolis, Minnesota;

How endurance training alters muscle lipid metabolism while preserving insulin sensitivity remains unclear. Because acute miễn phí fatty acid (FFA) elevation by lipid infusion reduces insulin sensitivity, we hypothesized that training status would alter accumulation of muscle triacylglycerol (TAG), diacylglycerol (DAG), ceramide, & acylcarnitine during ađáng yêu FFA elevation. Trained (n = 15) and sedentary (n = 13) participants matched for age, sex, & BMI received either a 6-h infusion of lipid (20% Intralipid at 90 ml/h) or glycerol (2.25 g/100 ml at 90 ml/h) during a hyperinsulinemic euglycemic clamp. Muscle biopsies were taken at 0, 120, & 360 min after infusion initiation to measure intramyocellular concentrations of TAG, DAG, ceramides, and acylcarnitines by liquid chromatography-tandem mass spectrometry. Trained participants had a higher Vo2 max and insulin sensitivity than sedentary participants. The lipid infusion produced a comparable elevation of FFA (594 ± 90 μmol/l in trained, 721 ± 30 μmol/l in sedentary, P = 0.4) và a decline in insulin sensitivity (-44.7% trained vs. -47.2% sedentary, P = 0.89). In both groups, lipid infusion increased the linoleic và linolenic acid nội dung of TAG without changing total TAG. In the sedentary group, lipid infusion increased total, oleic, và linoleic acid and linolenic acid nội dung of DAG. Regardless of training status, lipid infusion did not alter total ceramide, saturated ceramide, palmitoyl-carnitine, or oleoyl-carnitine. We conclude that during adễ thương FFA elevation, trained adults have sầu a similar decline in insulin sensitivity with less accumulation of muscle DAG than sedentary adults, suggesting that lipid-induced insulin resistance can occur without elevation of total muscle DAG.